Matthias Schmitz Selected Research

Fatal Familial Insomnia

1/2022	Plasma neurofilament light chain as a biomarker for fatal familial insomnia.
1/2022	Diagnostic accuracy of cerebrospinal fluid biomarkers in genetic prion diseases.
1/2021	TREM2 expression in the brain and biological fluids in prion diseases.
11/2019	Evaluation of Human Cerebrospinal Fluid Malate Dehydrogenase 1 as a Marker in Genetic Prion Disease Patients.
1/2018	Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis.
1/2016	Identification of new molecular alterations in fatal familial insomnia.
5/2014	Association of prion protein genotype and scrapie prion protein type with cellular prion protein charge isoform profiles in cerebrospinal fluid of humans with sporadic or familial prion diseases.

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Matthias Schmitz Research Topics

Disease

30	Prion Diseases (Transmissible Spongiform Encephalopathies) 04/2022 - 06/2010
20	Sporadic Creutzfeldt-Jakob Disease 09/2022 - 06/2010
20	Dementia (Dementias) 05/2022 - 01/2011
18	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2022 - 06/2014
13	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2011
11	Parkinson Disease (Parkinson's Disease) 05/2022 - 11/2016
10	Synucleinopathies 01/2022 - 01/2016
10	Scrapie 04/2020 - 05/2014
9	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 01/2022 - 06/2010
7	Fatal Familial Insomnia 01/2022 - 05/2014
6	Disease Progression 05/2022 - 05/2015
5	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 09/2020 - 09/2015
4	Cognitive Dysfunction 05/2022 - 03/2016
4	Brain Diseases (Brain Disorder) 04/2022 - 07/2013
4	Proteostasis Deficiencies 11/2021 - 01/2016
3	Tauopathies 01/2018 - 01/2016
3	Inflammation (Inflammations) 01/2017 - 02/2013
2	Acquired CJD 12/2020 - 01/2011
2	Infections 12/2020 - 01/2016
2	Frontotemporal Dementia (Semantic Dementia) 09/2020 - 03/2016
2	Neuroblastoma 04/2020 - 01/2017
2	Pathologic Processes 09/2018 - 03/2016
1	Mixed Dementias 01/2022
1	Amyloid Plaque 11/2021
1	Metabolic Diseases (Metabolic Disease) 12/2020
1	Cerebrovascular Trauma 01/2020
1	Lewy Body Disease (Lewy Body Dementia) 01/2020
1	Neuroinflammatory Diseases 11/2019
1	Mental Disorders (Mental Disorder) 01/2018
1	Neoplasms (Cancer) 11/2017
1	Essential Tremor (Essential Tremors) 11/2016
1	Multiple System Atrophy 11/2016
1	Hemolysis 05/2016
1	Rare Diseases (Rare Disease) 01/2016
1	Ischemic Stroke 09/2015

Drug/Important Bio-Agent (IBA)

29	Biomarkers (Surrogate Marker)IBA 09/2022 - 01/2011
26	Prion ProteinsIBA 04/2022 - 06/2010
12	SynucleinsIBA 05/2022 - 10/2015
12	PrionsIBA 04/2022 - 06/2014
9	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2014
8	Codon (Codons)IBA 01/2022 - 06/2010
7	Amyloid (Amyloid Fibrils)IBA 01/2022 - 01/2011
6	Protein Isoforms (Isoforms)IBA 11/2019 - 06/2010
4	tau Proteins (tau Protein)IBA 01/2022 - 01/2011
4	alpha-SynucleinIBA 01/2021 - 01/2019
3	Apolipoproteins E (ApoE)IBA 01/2022 - 01/2011
3	14-3-3 Proteins (14-3-3 Protein)IBA 02/2020 - 01/2011
3	Peptide Hydrolases (Proteases)FDA Link 10/2017 - 07/2013
2	Glial Fibrillary Acidic ProteinIBA 01/2022 - 01/2021
2	Lipocalin-2IBA 01/2022 - 01/2020
2	Biological ProductsIBA 01/2021 - 04/2020
2	Glycoproteins (Glycoprotein)IBA 01/2020 - 11/2017
2	Malate Dehydrogenase (Dehydrogenase, Malate)IBA 11/2019 - 11/2016
2	EnzymesIBA 11/2019 - 11/2016
2	Protein AggregatesIBA 01/2018 - 03/2016
2	Doxycycline (Periostat)FDA LinkGeneric 02/2017 - 01/2016
2	ProteomeIBA 01/2017 - 01/2017
2	Pharmaceutical PreparationsIBA 11/2016 - 12/2008
2	Methionine (L-Methionine)FDA Link 01/2016 - 05/2014
2	CytokinesIBA 09/2015 - 10/2014
2	ApolipoproteinsIBA 01/2015 - 01/2011
1	AntioxidantsIBA 04/2022
1	carnosolIBA 04/2022
1	salvinIBA 04/2022
1	amyloid beta-protein (1-42)IBA 01/2022
1	Calcium-Binding ProteinsIBA 01/2022
1	Chitinase-3-Like Protein 1IBA 01/2022
1	IronIBA 12/2021
1	Ferritins (Ferritin)IBA 12/2021
1	LigandsIBA 11/2021
1	Cell Surface ReceptorsIBA 01/2021
1	Messenger RNA (mRNA)IBA 12/2020
1	poly(propyleneimine)IBA 04/2020
1	Chromogranin AIBA 01/2020
1	ImmunosorbentsIBA 11/2019
1	NeurograninIBA 01/2019
1	RNA (Ribonucleic Acid)IBA 01/2019
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2019
1	Phosphotransferases (Kinase)IBA 05/2018
1	Lim KinasesIBA 05/2018
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 05/2018
1	MicroRNAs (MicroRNA)IBA 01/2018
1	ChitinasesIBA 11/2017
1	Flavin-Adenine Dinucleotide (FAD)IBA 01/2017
1	CathepsinsIBA 01/2017
1	CalpainIBA 01/2017
1	CalciumIBA 01/2017
1	PresenilinsIBA 01/2017
1	Hazardous Substances (Hazardous Materials)IBA 11/2016
1	AlbuminsIBA 11/2015
1	Interleukin-4 (Interleukin 4)IBA 09/2015
1	Interleukin-8 (Interleukin 8)IBA 09/2015
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 09/2015
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 09/2015
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 09/2015
1	Interleukin-6 (Interleukin 6)IBA 09/2015
1	Interleukin-5 (Interleukin 5)IBA 09/2015
1	Interferon-gamma (Interferon, gamma)IBA 09/2015
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2015

Therapy/Procedure

3	Therapeutics 01/2022 - 01/2018